Key result
Aortic valve reconstruction with autologous pericardium for bicuspid aortic valve reduced the mean peak pressure gradient from 71.1 mmHg preoperatively to 13.9 mmHg at 3 years, with a 99.0% freedom from reoperation rate at 5 years.
Why the study?
Does aortic valve reconstruction with autologous pericardium improve hemodynamics and clinical outcomes in patients with bicuspid aortic valve?
Cohort (n=102)
No
Does aortic valve reconstruction with autologous pericardium improve hemodynamics and clinical outcomes in patients with bicuspid aortic valve?
Absolute Event Rate: 13.9% vs 71.1%
Aortic valve reconstruction using autologous pericardium (tricuspidization) for bicuspid aortic valve demonstrates excellent medium-term hemodynamics and a 99% freedom from reoperation rate at 5 years.
May support autologous pericardial reconstruction in bicuspid aortic valve; leaves open need for randomized comparisons.
BACKGROUND: This study describes the surgical treatment of bicuspid aortic valve with original aortic valve reconstruction. METHODS AND RESULTS: Aortic valve reconstruction was done in 102 patients with bicuspid aortic valve from April 2007 through September 2011. Thirty-four patients with ascending aortic diameter >45 mm underwent hemi-arch aortic replacement concomitantly. Seventy-seven patients had aortic stenosis, and 25 had aortic regurgitation (AR). Mean age was 63.7±10.0 years old. There were 55 men and 47 women. Harvested pericardium is treated with 0.6% glutaraldehyde solution. The distance between commissures is measured with an original sizing instrument. For bicuspid valve with raphe, the raphe is considered as a commissure in order to measure the distance between each commissure. Without a raphe, we create a new annular margin and commissure using coronary ostium and the sizing instrument as a guide. Then, pericardium is trimmed with original template. Three cusps are sutured independently. The preoperative averaged peak pressure gradient of 71.1±39.0 mmHg was decreased to 16.2±8.8, 13.3±6.0, and 13.9±5.6 mmHg, respectively 1 week, 1 year, and 3 years after operation. AR was trivial. One reoperation was recorded. Mean follow-up was 733 days. There were 5 late mortalities. No thromboembolic event was recorded. CONCLUSIONS: Medium-term results were excellent. Tricuspidization gave good opening and closure of aortic valve with excellent hemodynamics.
No takes yet. Share an insight, caveat, or question.
Ozaki et al. (2014) conducted a cohort in Bicuspid aortic valve (n=102). Aortic valve reconstruction with glutaraldehyde-treated autologous pericardium vs. Preoperative baseline was evaluated on Peak pressure gradient at 3 years. Aortic valve reconstruction with autologous pericardium for bicuspid aortic valve reduced the mean peak pressure gradient from 71.1 mmHg preoperatively to 13.9 mmHg at 3 years, with a 99.0% freedom from reoperation rate at 5 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: