Key result
Intravenous propranolol (0.13 mg/kg) significantly reduced splanchnic blood flow, oxygen consumption, cardiac output, and heart rate, while elevating splanchnic vascular resistance in normal men.
Why the study?
Does intravenous propranolol alter splanchnic hemodynamics and oxygen consumption in normal men?
Population
20 normal, fasting, conscious men
Comparison
Intravenous propranolol, with or without… vs Baseline/untreated state
Design
Other
Authors
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Findings in healthy volunteers warrant caution before clinical extrapolation; leaves open net effects of beta-blockade on splanchnic oxygen balance in disease.
Does intravenous propranolol alter splanchnic hemodynamics and oxygen consumption in normal men?
Propranolol administration in normal men reduces splanchnic blood flow and oxygen consumption, suggesting the splanchnic circulation is influenced by both alpha (vasoconstriction) and beta (vasodilation) adrenergic receptors.
Price et al. (1967) studied Healthy volunteers (n=20). Propranolol vs. Baseline / Pretreatment conditions (glucose, phenoxybenzamine, hexamethonium) was evaluated on Splanchnic blood flow, oxygen consumption, cardiac output, and heart rate. Intravenous propranolol (0.13 mg/kg) significantly reduced splanchnic blood flow, oxygen consumption, cardiac output, and heart rate, while elevating splanchnic vascular resistance in normal men.
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