Key result
Expression of p57Kip2 induced marked reorganization of actin filaments and translocation of LIMK-1 from the cytoplasm to the nucleus, unlike p27Kip1 or a p57 mutant.
Population
Preclinical cellular model (context of mouse embryogenesis)
Comparison
Expression of p57 vs Expression of p27Kip1 or a p57 mutant with a…
Design
Preclinical
Authors
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Hypothesis-generating for p57Kip2 in embryogenesis; leaves open relevance to human cardiovascular development.
p57Kip2 regulates actin dynamics by binding and translocating LIMK-1 to the nucleus, suggesting a dual role in cell cycle regulation and actin dynamics during embryogenesis.
Yokoo et al. (2003) studied this question. p57Kip2 expression vs. p27Kip1 or p57 mutant was evaluated on Reorganization of actin filament and translocation of LIMK-1. Expression of p57Kip2 induced marked reorganization of actin filaments and translocation of LIMK-1 from the cytoplasm to the nucleus, unlike p27Kip1 or a p57 mutant.
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