Key result
Dietary fish oil significantly reduced the ventricular-to-body weight ratio in JVS mice compared to standard diet (7.7 vs. 9.9 mg/g, P<0.01), attenuating cardiac hypertrophy.
Why the study?
Does dietary fish oil attenuate cardiac hypertrophy in a mouse model of lipotoxic cardiomyopathy?
Population
Juvenile visceral steatosis mice and control mice
Comparison
Dietary fish oil starting at 4 weeks of age vs Standard diet starting at 4 weeks of age
Design
Preclinical
Follow-up
4 weeks (from 4 to 8 weeks of age)
Authors
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Does not support fish oil for hypertrophy in patients; leaves open its role in lipotoxic cardiomyopathy models.
Does dietary fish oil attenuate cardiac hypertrophy in a mouse model of lipotoxic cardiomyopathy?
Absolute Event Rate: 7.7% vs 9.9%
p-value: p=<0.01
Dietary fish oil attenuates cardiac hypertrophy and improves survival in a mouse model of lipotoxic cardiomyopathy by modifying myocardial DAG composition and inhibiting PKC redistribution.
TAKAHASHI et al. (2005) studied Lipotoxic cardiomyopathy due to systemic carnitine deficiency. Dietary fish oil vs. Standard diet was evaluated on Ventricular-to-body weight ratio at 8 weeks of age (p=<0.01). Dietary fish oil significantly reduced the ventricular-to-body weight ratio in JVS mice compared to standard diet (7.7 vs. 9.9 mg/g, P<0.01), attenuating cardiac hypertrophy.
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