Key result
Purified gambir administered at 2.5 mg/kg BW for 14 days significantly reduced systolic blood pressure by 24% compared to 5% in the negative control group in prednisone salt-induced hypertensive rats.
Why the study?
Purified gambier holds potential for treating hypertension through antioxidant bioactivity, but its antihypertensive performance and correlation with antioxidant activity in hypertensive models required investigation.
Does purified gambir reduce blood pressure in prednisone salt-induced hypertensive rats?
Does purified gambir reduce blood pressure in prednisone salt-induced hypertensive rats?
Absolute Event Rate: 24% vs 5%
p-value: p=<0.05
Purified gambir demonstrated significant antihypertensive effects and increased nitric oxide bioavailability in a rat model of prednisone salt-induced hypertension, with the lowest tested dose (2.5 mg/kg) showing the greatest efficacy.
This preclinical finding is strictly hypothesis-generating for human hypertension; leaves open whether gambir.
Introduction: Purified gambier (Uncaria gambir Roxb.) is potential for treating hypertension based on its antioxidant bioactivity. In this study, we investigated the antihypertensive performances of purified gambier on hypertensive rats and the correlation with its antioxidant activity. Methods: Rats (2-3 months old and the bodyweight of 200-250 g) were divided into five groups. Groups 1, 2, and 3 were treated orally with water suspension of purified gambier at doses of 2.5; 5; and 10 mg/kg BW once a day for 14 days, group 4 and 5 were acted as positive control (treated with vehicle) and captopril treated group (comparison) respectively. The systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), blood flow (BF) and blood volume (BV) were recorded once a day before and 1,3,7 and 14 days after commencement. The blood was taken before and at the end of recording for the plasma NO measurement. Two-way ANOVA was used to analyze the changes of those parameters, except for plasma NO analyzes by one-way ANOVA, followed by Duncan multirange test (95% confidence interval). Results: The study showed that significant antihypertensive effects (p<0.05), influenced by doses and gambier administration duration. The plasma NO of animals was increased after administration of purified gambier (p<0.05), although there was no significant difference in plasma NO in doses variation. Conclusion: These indicated that purified gambier proceed antioxidant associated antihypertensive effects at doses of 2.5 – 10 mg/kg BW when administered for 14 days on the salt-prednisone induced hypertensive rats. KEYWORDS: antioxidant, antihypertensive, purified gambier, Uncaria gambir Roxb., salt-prednisone induced, hypertension rat
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Permatasari et al. (2022) studied Prednisone salt-induced hypertension (n=15). Purified gambir (Uncaria gambir Roxb.) vs. 0.5% Na-CMC suspension (negative control) and Captopril 2.25 mg/kg BW (positive control) was evaluated on Percentage decrease in Systolic Blood Pressure (SBP) on day 14 (p=<0.05). Purified gambir administered at 2.5 mg/kg BW for 14 days significantly reduced systolic blood pressure by 24% compared to 5% in the negative control group in prednisone salt-induced hypertensive rats.
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