Key result
The highest percentile of normalized endogenous thrombin potential was associated with a 2.4-fold increased odds of previous myocardial infarction compared to the lowest category.
Why the study?
Does a previous myocardial infarction associate with increased in vitro thrombin generation in plasma compared to matched controls?
Population
356 subjects from the North Glasgow MONICA study, comprising 171 cases with a previous myocardial infarction…
Comparison
Previous myocardial infarction (cases) vs Age- and sex-matched controls without a history…
Design
Case-control
Authors
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May indicate persistent post-MI hypercoagulability; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=356)
No
Does a previous myocardial infarction associate with increased in vitro thrombin generation in plasma compared to matched controls?
Odds Ratio: 2.4 (95% CI 1.3–4.5)
Patients with a previous myocardial infarction exhibit sustained increased thrombin generation potential 3 to 9 months post-event, suggesting a persistent hypercoagulable state.
Smid et al. (2013) conducted a case-control in Myocardial Infarction (n=356). Highest percentile of normalized endogenous thrombin potential (ETP) vs. Lowest category of normalized ETP was evaluated on Previous myocardial infarction (adjusted OR 2.4, 95% CI 1.3-4.5). The highest percentile of normalized endogenous thrombin potential was associated with a 2.4-fold increased odds of previous myocardial infarction compared to the lowest category.
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