Key result
Voglibose therapy improved glycemic control, reduced heart and lung weight ratios, improved left ventricular function, and decreased myocardial oxidative stress in mice with cardiac pressure overload.
Why the study?
Does voglibose improve cardiac remodeling and function in mice with pressure overload-induced heart failure?
Does voglibose improve cardiac remodeling and function in mice with pressure overload-induced heart failure?
Voglibose therapy attenuates cardiac remodeling and improves left ventricular function in a mouse model of pressure overload by decreasing myocardial oxidative stress.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in pressure-overload mice; leaves open translation to human HF and does not support clinical use.
Liao et al. (2006) studied Cardiac hypertrophy and heart failure. Voglibose vs. Transverse aortic constriction without voglibose was evaluated on Cardiac remodeling, left ventricular function, and myocardial oxidative stress. Voglibose therapy improved glycemic control, reduced heart and lung weight ratios, improved left ventricular function, and decreased myocardial oxidative stress in mice with cardiac pressure overload.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: