Key result
A single 10-mg dose of oral nifedipine for hypertensive urgency was associated with ischemic strokes on two occasions in a 44-year-old man with no prior cerebrovascular disease.
Why the study?
Does a single dose of oral nifedipine cause ischemic stroke in patients with hypertensive urgency?
Case Report (n=1)
Does a single dose of oral nifedipine cause ischemic stroke in patients with hypertensive urgency?
A single 10-mg dose of oral nifedipine for hypertensive urgency may precipitate ischemic stroke, highlighting the need for caution even in young patients without prior cerebrovascular disease.
Nifedipine use in hypertensive urgency warrants caution; this case leaves open questions of causality and generalizability.
To the Editor.—Jaker and coworkers1have confirmed earlier studies showing that a single 10-mg dose of oral nifedipine is effective and safe for the treatment of hypertensive urgency. However, there are recent reports of complications related to this treatment: cerebral ischemia2or retinal ischemia3occurring in the absence of hypotension, severe hypotension following repeated doses given over a short time interval,4and hypotension following a single oral dose of nifedipine.5While these complications represent the exception to the currently safe use of nifedipine, caution is recommended in the treatment of hypertensive urgency, particularly in the elderly and those with coronary or cerebrovascular disease.1We present the case of a young hypertensive man with no history of cerebrovascular disease, who had, on two occasions, ischemic strokes coincident with the use of a single 10-mg capsule of nifedipine. Report of a Case.—A 44-year-old white
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Miguel Schwartz (1990) conducted a case report in Hypertensive urgency (n=1). Oral nifedipine was evaluated on Ischemic stroke. A single 10-mg dose of oral nifedipine for hypertensive urgency was associated with ischemic strokes on two occasions in a 44-year-old man with no prior cerebrovascular disease.
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