Key result
Low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state unable to bind actin.
Low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state.
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Provides a mechanistic basis for cold-induced muscle weakness; leaves open whether targeting this myosin refractory.
study reveals that low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state unable to bind actin.
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Ben Short (2019) studied this question. Low temperatures reduce force production in mammalian skeletal muscle by trapping myosin motors in a refractory state unable to bind actin.
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