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A convenient synthesis of cytotoxic pyrroloquinazolinoquinoline alkaloid, luotonin A ( I ) , was achieved in 3 steps; (i) reaction of anthranilic acid with 0-methylbutyrolactim to deoxyvasicinone, (ii) oxidation of deoxyvasicinone, and (iii) formation of luotonin A by the reaction of vasicinone with anthranyl aldehyde.Luotonins A (1) and B (2) are novel pyrroloquinazolinoquinoline alkaloids isolated from Peganum nigellastm and 1 showed cytotoxic activity against mouse leukemia P-388 cells (IC50 1.8 pg,/m~).lThe
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Nomura et al. (1999) studied this question.
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