Key result
Spinal anesthesia with bupivacaine significantly decreased coronary perfusion pressure during CPR in dogs compared to saline, with only 36% vs 100% achieving CPP ≥15 mm Hg.
Why the study?
Does spinal anesthesia with bupivacaine reduce coronary perfusion pressure during CPR in dogs compared to sham spinal injection?
Population
20 mongrel dogs, anesthetized, subjected to electrically induced ventricular fibrillation and…
Comparison
Spinal injection with 0.5 mg/kg bupivacaine… vs Spinal injection with an equivalent volume of…
Design
Preclinical, randomly assigned
Follow-up
10 minutes of CPR
Authors
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May caution against spinal bupivacaine in arrest-prone settings; leaves open human translation and epinephrine optimization.
RCT (n=20)
randomly assigned
Does spinal anesthesia with bupivacaine reduce coronary perfusion pressure during CPR in dogs compared to sham spinal injection?
Absolute Event Rate: 36% vs 100%
Spinal anesthesia significantly decreases coronary perfusion pressure during CPR in a canine model, which can be improved with escalating doses of intravenous epinephrine.
Rosenberg et al. (1996) conducted an RCT in Cardiac arrest during spinal anesthesia (n=20). Spinal bupivacaine vs. Normal saline was evaluated on Coronary perfusion pressure (CPP) ≥ 15 mm Hg during the first 4 min after arrest. Spinal anesthesia with bupivacaine significantly decreased coronary perfusion pressure during CPR in dogs compared to saline, with only 36% vs 100% achieving CPP ≥15 mm Hg.
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