Population
Scallop adductor muscle myofibrils with native regulatory light chain replaced by chicken gizzard RLC…
Design
Preclinical
Authors
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Biophysical myosin dynamics in animal muscle leave open their role in human cardiac contraction; further mechanistic studies required before clinical relevance.
The study provides biophysical evidence that muscle contraction is accompanied by a disorder-to-order transition of the myosin head, with the light-chain domain rotating relative to the catalytic domain.
Ramachandran et al. (1999) studied this question.