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May 20, 2014Journal of Neuroscience Research

The low-dose combination of olmesartan plus azelnidipine demonstrated a greater synergistic benefit than monotherapy with a low-dose of olmesartan or azelnidipine in preventing spontaneous infarct volume and reducing oxidative stresses.

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Why the study?

Does combined treatment with olmesartan plus azelnidipine reduce spontaneous infarct volume and oxidative stress in stroke-prone spontaneously hypertensive rats?

Population

Stroke-prone spontaneously hypertensive rats (SHR-SP)

Comparison

Olmesartan and azelnidipine monotherapy and… vs Vehicle group

Design

Preclinical

Authors

YOYoshio OmoteKDKentaro DeguchiSKSyoichiro Kono

Discussion

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Overview

Does not change clinical practice; leaves open translation of synergistic neuroprotection to human trials.

Structured PICO

Does combined treatment with olmesartan plus azelnidipine reduce spontaneous infarct volume and oxidative stress in stroke-prone spontaneously hypertensive rats?

P
Population
Stroke-prone spontaneously hypertensive rats (SHR-SP)
I
Intervention
Olmesartan and azelnidipine monotherapy (2 mg/kg or 10 mg/kg each) and their combination therapy (1 mg/kg each)
C
Comparator
Vehicle group
O
Outcome
Spontaneous infarct volume, oxidative stress, inflammation, and neurovascular unit componentssurrogate

A low-dose combination of olmesartan and azelnidipine provides synergistic neuroprotective effects, reducing infarct volume and oxidative stress in a rat model of stroke.

Cite This Study

Omote et al. (2014) studied this question.

synapsesocial.com/papers/6a8e73e63d91093f4f11db8ehttps://doi.org/10.1002/jnr.23406
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination Therapy of Olmesartan and Azelnidipine Inhibits Sympathetic Activity Associated with Reducing Oxidative Stress in the Brain of Hypertensive Rats2012 · 7 citations
  2. 2Renoprotective Effect of Azelnidipine in Rats2008 · 6 citations
  3. 3Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice2005 · 47 citations
  4. 4The Impact of Combined Treatment with Atorvastatin and Amlodipine in Stroke-prone Spontaneously Hypertensive Rats2014 · 1 citations
  5. 5Calcium Channel Blockers, More than Diuretics, Enhance Vascular Protective Effects of Angiotensin Receptor Blockers in Salt-Loaded Hypertensive Rats2012 · 8 citations