Population
Isolated guinea pig ventricular myocytes
Comparison
Conventional whole cell patch-clamp technique vs Perforated patch-clamp technique
Design
Preclinical
Follow-up
up to 60 min
Authors
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Conventional patch-clamp may confound autonomic regulation studies in myocytes; leaves open whether perforated techniques better reflect native physiology.
Conventional whole-cell patch-clamp techniques alter the concentration dependence of autonomic regulation of ion channels in cardiac myocytes due to cell dialysis.
Zakharov et al. (1995) studied this question.
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