Population
Cultured vascular smooth muscle cells (VSMC) and adjacent endothelial cells (EC) in a coculture system
Comparison
Prolonged incubation with interleukin-1 or… vs NG-Monomethyl-L-arginine or EC alone
Design
Preclinical
Authors
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IL-1-driven NO from VSMC may promote EC proliferation; leaves open relevance to human plaque neovascularization.
Nitric oxide released from vascular smooth muscle cells induces cell death and bFGF release, stimulating endothelial cell proliferation, suggesting a mechanism for neovascularization in atherosclerotic plaques.
Fukuo et al. (1995) studied this question.
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