Population
Coronary venular endothelial cells (CVECs)
Comparison
NO donor sodium nitroprusside and vasodilating… vs Anti-bFGF antibodies or NO synthase inhibitor N…
Design
Preclinical
Authors
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NO-bFGF-uPA signaling may mediate shear-driven coronary endothelial proliferation; leaves open in vivo translation and therapeutic angiogenesis applications.
Nitric oxide promotes cell proliferation and uPA upregulation in coronary venular endothelial cells by inducing endogenous bFGF, providing a potential link between shear rate, NO, and coronary angiogenesis.
Ziche et al. (1997) studied this question.
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