Key result
Muscimol infused into the NTS and NPBmed produced significantly lesser bradycardia and decreases in MAP in 24-month-old rats compared to 3-month-old rats.
Aging is associated with an impairment of GABA-ergic mechanisms involved in cardiovascular regulation in the NTS and NPBmed in rats.
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Suggests age-related brainstem GABAergic impairment in rats; hypothesis-generating for autonomic dysfunction in human aging, no practice change.
Mollace et al. (1991) studied this question. Muscimol vs. 3 month old rats (young control) was evaluated on Mean arterial blood pressure (MAP) and heart rate (HR). Muscimol infused into the NTS and NPBmed produced significantly lesser bradycardia and decreases in MAP in 24-month-old rats compared to 3-month-old rats.
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