Population
Awake rats
Comparison
Bilateral microinjections of muscimol or… vs Baseline responses prior to microinjection
Design
Preclinical
Follow-up
Up to 60 minutes post-microinjection
Authors
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Should not inform clinical chemoreflex modulation; leaves open receptor-specific NTS targeting in autonomic disease models.
In awake rats, GABAA receptors in the NTS mediate the parasympathetic bradycardic component of the chemoreflex, while GABAB receptors modulate the pressor response.
Callera et al. (1999) studied this question.
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