Key result
Injection of baclofen into the caudal NTS reduced or prevented PDG-evoked apnea and diminished bradycardia, suggesting GABA B receptors modulate vagal C fiber mediated reflexes in rats.
Population
Urethane-anesthetized Wistar rats
Comparison
-baclofen injected bilaterally into the nucleus… vs Baseline response to phenyldiguanide before…
Design
Preclinical
Authors
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Should not alter clinical practice; hypothesis-generating for GABA B modulation of vagal reflexes in humans.
GABA B receptors in the nucleus tractus solitarius modulate vagal C fiber-mediated cardiorespiratory reflexes, specifically apnea and bradycardia, in rats.
Seifert et al. (1995) studied this question. (-)-baclofen vs. Baseline (before injections) / CGP 35348 was evaluated on Cardiorespiratory response to C fiber stimulation with phenyldiguanide (PDG). Injection of baclofen into the caudal NTS reduced or prevented PDG-evoked apnea and diminished bradycardia, suggesting GABA B receptors modulate vagal C fiber mediated reflexes in rats.
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