Key result
Injection of 0.5 nM baclofen into the fourth ventricle of intact rats increased arterial blood pressure, heart rate, and inspiratory activity, which was reversed by CGP35348.
Why the study?
Does baclofen modulate cardiorespiratory functions in intact, spontaneously breathing rats?
Population
Urethane-anesthetized intact, spontaneously breathing Wistar rats
Comparison
Repeated injections of 0.5 nM baclofen and 50 nM… vs Control values (baseline before injection)
Design
Preclinical
Authors
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Central GABAB activation may modulate cardiorespiratory parameters in intact rats; leaves open translation to human physiology or therapy.
Does baclofen modulate cardiorespiratory functions in intact, spontaneously breathing rats?
Baclofen exerts excitatory cardiovascular and respiratory effects in intact rats, suggesting that GABAB receptors modulate the depth and duration of inspiration.
Trippenbach et al. (1994) studied Cardiorespiratory function. Baclofen and CGP35348 vs. Control values was evaluated on Arterial blood pressure, heart rate, inspiratory time, and diaphragmatic EMG. Injection of 0.5 nM baclofen into the fourth ventricle of intact rats increased arterial blood pressure, heart rate, and inspiratory activity, which was reversed by CGP35348.
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