Key result
Microinjection of baclofen into the NTS produced a significantly greater pressor response in rats with acute hypertension (39+/-5 mm Hg) compared to normotensive controls (22+/-1 mm Hg, P<0.01).
Population
Sprague-Dawley rats, anesthetized, paralyzed, and artificially ventilated, with unilateral electrolytic…
Comparison
Microinjection of 40 pmol baclofen into the… vs Normotensive control rats; comparisons also made…
Design
Preclinical
Authors
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Enhances preclinical insight into NTS GABA-B signaling in hypertension; leaves open translation to human BP regulation.
Absolute Event Rate: 39% vs 22%
p-value: p=<0.01
Acute and chronic hypertension enhance the pressor response to GABA-B receptor activation in the NTS, with acute effects driven by presynaptic mechanisms and chronic effects involving both pre- and postsynaptic changes.
Vitela et al. (2001) studied Hypertension (n=56). Baclofen microinjection into the NTS vs. Normotensive controls was evaluated on Baclofen-induced pressor response (BIPR) (p=<0.01). Microinjection of baclofen into the NTS produced a significantly greater pressor response in rats with acute hypertension (39+/-5 mm Hg) compared to normotensive controls (22+/-1 mm Hg, P<0.01).
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