Key result
High-dose IV baclofen markedly increases BP and HR via central sympathetic activation in anesthetized rats.
Why the study?
The cardiovascular responses to baclofen in anaesthetized rats were investigated to understand its effects on blood pressure and heart rate.
Does intravenous baclofen affect blood pressure and heart rate in anaesthetized rats?
Does intravenous baclofen affect blood pressure and heart rate in anaesthetized rats?
High doses of intravenous baclofen produce centrally-mediated sympathetic increases in blood pressure and heart rate in rats.
Authors
No takes yet. Share an insight, caveat, or question.
Alerts to central sympathetic effects of baclofen in rat models; leaves open translation to human anesthesia.
Chahl et al. (1980) studied this question. Baclofen was evaluated on Blood pressure and heart rate. High doses of intravenous baclofen produced a marked and prolonged increase in blood pressure and heart rate of central sympathetic origin in anaesthetized rats.
Synapse has enriched one closely related paper. Consider it for comparative context: