Key result
Intracerebroventricular GABA and intraperitoneal AOAA depressed ventilation in halothane-anesthetized rats, primarily by decreasing respiratory frequency due to prolonged expiratory duration.
Population
Halothane-anesthetized rats
Design
Preclinical
Authors
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Warrants vigilance for respiratory effects of GABA-modulating drugs in anesthesia; leaves open central mechanisms for human studies.
Increased endogenous concentrations of GABA decrease respiratory frequency due to a prolongation in expiratory duration.
Hedner et al. (1984) studied Halothane-anesthetized rats. Intracerebroventricular GABA or intraperitoneal AOAA was evaluated on Ventilation depression (respiratory frequency and tidal volume). Intracerebroventricular GABA and intraperitoneal AOAA depressed ventilation in halothane-anesthetized rats, primarily by decreasing respiratory frequency due to prolonged expiratory duration.
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