Key result
Acute volume expansion increased blood pressure (+15/8 mm Hg) and blunted sodium elimination (51% vs 86%) in heart transplant recipients compared to controls (p<=0.05).
Why the study?
Does acute volume expansion reveal abnormal blood pressure and fluid homeostasis responses in heart transplant recipients compared to liver transplant recipients and normal volunteers?
Population
10 stable heart transplant recipients, 6 liver transplant recipients receiving similar doses of…
Comparison
Acute volume expansion after 3 days of a… vs Liver transplant recipients on cyclosporine and…
Design
Cohort
Follow-up
48 hours post-infusion
Authors
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Supports impaired volume homeostasis in heart transplant recipients; hypothesis-generating for denervation effects pending prospective trials.
Observational (n=23)
Does acute volume expansion reveal abnormal blood pressure and fluid homeostasis responses in heart transplant recipients compared to liver transplant recipients and normal volunteers?
p-value: p=<=0.05
Heart transplant recipients exhibit salt-sensitive hypertension and blunted natriuretic responses to volume expansion, likely due to cardiac denervation rather than cyclosporine use alone.
Braith et al. (1996) conducted an observational in Heart transplantation (n=23). Acute volume expansion (saline infusion) vs. Liver transplant recipients and normal volunteers was evaluated on Change in blood pressure and sodium elimination after saline infusion (p=<=0.05). Acute volume expansion increased blood pressure (+15/8 mm Hg) and blunted sodium elimination (51% vs 86%) in heart transplant recipients compared to controls (p<=0.05).
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