Key result
Atriopeptin II infusion in conscious rats caused hypotension (-27%) driven solely by decreased cardiac output (-34%), with a later-developing bradycardia reversible by atropine.
Why the study?
Does atriopeptin II infusion alter hemodynamic and renal excretory responses in conscious rats?
Population
5 chronically instrumented conscious rats
Comparison
150-min atriopeptin II infusion with and without… vs Vehicle in the same rats
Design
Preclinical
Follow-up
150 minutes
Authors
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Atriopeptin II may lower BP via reduced cardiac output in rats; leaves open translation to human hemodynamics or therapy.
Does atriopeptin II infusion alter hemodynamic and renal excretory responses in conscious rats?
Atriopeptin II induces hypotension in conscious rats via a cardioinhibitory effect (decreased cardiac output) rather than volume depletion or vasodilation.
Allen et al. (1987) studied this question. Atriopeptin II (AP II) infusion vs. Vehicle was evaluated on Hemodynamic and renal excretory responses (hypotension and cardiac output). Atriopeptin II infusion in conscious rats caused hypotension (-27%) driven solely by decreased cardiac output (-34%), with a later-developing bradycardia reversible by atropine.
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