Why the study?
Does Atriopeptin II produce hypotension by lowering total peripheral resistance in conscious sheep?
Population
Conscious chronically instrumented sheep
Comparison
Atriopeptin II infused into the right atrium for… vs Baseline and partial ganglionic blockade with…
Design
Preclinical
Follow-up
30 minutes
Authors
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Challenges vasodilator hypothesis in conscious sheep; leaves open translation to human physiology or therapy.
Does Atriopeptin II produce hypotension by lowering total peripheral resistance in conscious sheep?
Atriopeptin II induces hypotension in conscious sheep primarily by reducing venous return and cardiac output, rather than by lowering total peripheral resistance.
Breuhaus et al. (1985) studied this question.
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