Key result
In conscious spontaneously hypertensive rats, regional vasoconstrictor responses to atriopeptin II infusion are mediated by increases in sympathetic tone rather than direct vascular actions.
Population
Conscious spontaneously hypertensive rats, divided into control, 6-hydroxydopamine-treated, and…
Comparison
Infusion of synthetic atriopeptin II at 1… vs Responses compared between control, chemically…
Design
Preclinical
Authors
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Questions direct vascular effects of atriopeptin II in hypertension models; leaves open sympathetic mediation for translational research.
In conscious spontaneously hypertensive rats, regional vasoconstrictor responses to atriopeptin II infusion are mediated by increased sympathetic tone rather than direct vascular actions.
Lappe et al. (1985) studied Hypertension (spontaneously hypertensive rats). Atriopeptin II (AP II) vs. Control, chemically sympathectomized, and renal-denervated groups was evaluated on Mean arterial pressure and regional blood flow. In conscious spontaneously hypertensive rats, regional vasoconstrictor responses to atriopeptin II infusion are mediated by increases in sympathetic tone rather than direct vascular actions.
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