Key result
Induction of type 1 diabetes by withdrawing insulin in rats caused a progressive decrease in cardiac output to 85 +/- 5% of control levels by day 7, independent of volume or sodium loss.
Why the study?
Does the onset of type 1 diabetes decrease cardiac output and alter renal hemodynamics in rats?
Population
Streptozotocin-treated rats instrumented with a Transonic flow probe on the ascending aorta and with artery…
Comparison
Induction of type 1 diabetes by withdrawing… vs Control levels and recovery period
Design
Preclinical
Follow-up
7 days of diabetes induction
Authors
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Alerts to direct hemodynamic effects of insulin withdrawal in diabetes models; leaves open human relevance and mechanisms.
Does the onset of type 1 diabetes decrease cardiac output and alter renal hemodynamics in rats?
The onset of uncontrolled type 1 diabetes in rats causes a significant decrease in cardiac output that is not entirely dependent on volume or sodium loss, suggesting a role for peripheral vasoconstriction.
Brands et al. (2000) studied Type 1 diabetes. Induction of diabetes via withdrawal of intravenous insulin-replacement therapy vs. Control levels (prior to withdrawal) was evaluated on Cardiac output. Induction of type 1 diabetes by withdrawing insulin in rats caused a progressive decrease in cardiac output to 85 +/- 5% of control levels by day 7, independent of volume or sodium loss.
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