Key result
Chronic depression of adrenergic innervation in the rabbit saphenous artery induces supersensitivity due to partial depolarization caused by the loss of electrogenic Na+, K+ pumping.
Population
Rabbit saphenous artery model
Design
Review
Authors
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Should not alter clinical vascular management; leaves open translation of rabbit Na+,K+ pump mechanisms to human denervation supersensitivity.
This review highlights that vascular smooth muscle supersensitivity following adrenergic denervation is primarily driven by partial depolarization resulting from the loss of electrogenic Na+, K+ pumping.
William W. Fleming (2008) conducted a review in Vascular smooth muscle sensitivity. Chronic depression of adrenergic innervation was evaluated on Cellular sensitivity and membrane potential. Chronic depression of adrenergic innervation in the rabbit saphenous artery induces supersensitivity due to partial depolarization caused by the loss of electrogenic Na+, K+ pumping.
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