Key result
Normotensive African-Americans with a positive family history of hypertension manifested a greater increase in blood pressure and MSNA to cold stress compared to white subjects.
Why the study?
Does family history of hypertension affect the sympathetic response to cold pressor testing differently in normotensive black versus white subjects?
Population
34 normotensive subjects: black subjects with and without a positive family history of hypertension, and…
Comparison
Cold pressor testing vs Comparison between racial groups and family…
Design
Cross-sectional
Authors
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Hypothesis-generating for family history as modifier of racial sympathetic reactivity; leaves open prospective links to hypertension incidence.
Cross-Sectional (n=34)
Does family history of hypertension affect the sympathetic response to cold pressor testing differently in normotensive black versus white subjects?
The exaggerated sympathetic response to cold stress previously observed in normotensive African-Americans appears to be driven specifically by those with a positive family history of hypertension.
Calhoun et al. (1997) conducted a cross-sectional in Normotension (n=34). Black race with a positive family history of hypertension vs. White race and/or negative family history of hypertension was evaluated on Blood pressure and muscle sympathetic nerve activity (MSNA) responses to cold pressor testing. Normotensive African-Americans with a positive family history of hypertension manifested a greater increase in blood pressure and MSNA to cold stress compared to white subjects.
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