Key result
Immature granulocyte count was positively associated with Torque teno virus load (st.β = 0.45, P<0.001), while total granulocyte count was negatively associated (st.β = -0.39, P<0.001).
Why the study?
Torque teno virus (TTV) is proposed as an immune function biomarker for personalized immunosuppressive dosing after solid organ transplantation, but associations between TTV load and immature granulocytes or other leukocyte populations needed evaluation.
Is immature granulocyte count associated with Torque teno virus (TTV) load in solid organ transplant recipients?
Cross-Sectional (n=701)
Is immature granulocyte count associated with Torque teno virus (TTV) load in solid organ transplant recipients?
Effect estimate: st.β = 0.45
p-value: p=<0.001
Immature granulocyte count is positively associated with TTV load in solid organ transplant recipients, supporting the theory that TTV replicates in immature granulocytes.
This hypothesis-generating association between TTV load and immature granulocytes should not yet.
OBJECTIVES: Torque teno virus (TTV) is proposed as a biomarker of immune function, potentially aiding in personalized immunosuppressive dosing after solid organ transplantation. TTV is thought to replicate in leukocytes, particularly immature granulocytes. We primarily aimed to assess the association between immature granulocyte count and TTV load, while also exploring associations between TTV load and other leukocyte populations. METHODS: A total of 701 SOTR at 3 months post-transplantation were included from the TransplantLines Study for cross-sectional analyses. TTV load was measured by PCR assay (TTV R-GENE®, bioMérieux) and leukocytes were counted by a Sysmex XN hematology analyzer. Linear regression analyses were performed to assess associations. RESULTS: The mean age of the cohort was 57.0 ± 13.4 years, and 35.8% were female. In multivariable regression analyses, after adjusting for factors known to potentially influence TTV load, immature granulocyte count was positively associated with TTV load (st.β = 0.45, P < 0.001), while total granulocyte count was negatively associated (st.β=-0.39, P < 0.001). CONCLUSION: These results provide evidence to support the theory that TTV replicates in immature granulocytes. The negative association with total granulocyte count suggests possible antiviral effects or altered granulocyte lifespan. These relationships may help clinical interpretation of TTV as a marker of immune function.
No takes yet. Share an insight, caveat, or question.
Jonker et al. (2025) conducted a cross-sectional in Solid organ transplant recipients (n=701). Immature granulocyte count was evaluated on Association between immature granulocyte count and TTV load (st.β = 0.45, p=<0.001). Immature granulocyte count was positively associated with Torque teno virus load (st.β = 0.45, P<0.001), while total granulocyte count was negatively associated (st.β = -0.39, P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: