Key result
Pure autonomic failure was associated with significantly slower functional deterioration and a better prognosis compared to multiple system atrophy, including less progression to death (p=0.003).
Why the study?
Does the progression and prognosis of pure autonomic failure differ from multiple system atrophy?
Population
30 patients, including 8 with pure autonomic failure and 22 with probable multiple system atrophy matched…
Design
Cohort
Follow-up
more than seven years
Authors
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May aid prognostic counseling in autonomic failure; leaves open prospective validation of survival differences.
Cohort (n=30)
Does the progression and prognosis of pure autonomic failure differ from multiple system atrophy?
p-value: p=<0.0001
Pure autonomic failure has a distinct, slower progression of autonomic symptoms and a better prognosis compared to the steady progressive deterioration seen in multiple system atrophy.
Naoki Mabuchi (2005) conducted a cohort in Pure autonomic failure (PAF) and multiple system atrophy (MSA) (n=30). Pure autonomic failure vs. Multiple system atrophy was evaluated on Progression to modified Rankin scale grade III, IV, V, and death (p=<0.0001). Pure autonomic failure was associated with significantly slower functional deterioration and a better prognosis compared to multiple system atrophy, including less progression to death (p=0.003).
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