Key result
Pediatric heart transplantation using an organ from an influenza B-positive donor was performed, suggesting that donors with treatable infections may help expand the donor pool.
Why the study?
Heart transplantation demand is increasing without subsequent growth of the donor pool, driving a need to expand donor acceptance criteria especially for critically ill, highly sensitized patients.
Does heart transplantation from an influenza B-positive donor result in successful outcomes in pediatric patients?
Case Report (n=1)
Does heart transplantation from an influenza B-positive donor result in successful outcomes in pediatric patients?
Heart transplantation from donors with treatable infections like influenza B may be a viable strategy to expand the donor pool for critically ill patients.
May support expanding donor criteria for sensitized pediatric recipients; leaves open need for prospective validation before practice change.
As heart transplantation demand is increasing without subsequent growth of the donor pool, need for expansion of acceptance criteria is paramount, particularly when considering critically ill, highly sensitized patients. We present a case report of a pediatric heart transplant recipient of an organ refused by 197 prior potential recipients due to the donor being infected with influenza virus. We perform a literature review of recent solid organ transplant cases from influenza-positive donors and conclude that the donor pool may be expandable by allowing donors with treatable infections to be included.
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Smith et al. (2019) conducted a case report in Heart failure requiring transplantation (n=1). Heart transplantation from an influenza B-positive donor was evaluated. Pediatric heart transplantation using an organ from an influenza B-positive donor was performed, suggesting that donors with treatable infections may help expand the donor pool.
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