Key result
In ANG II-infused rats, a high-NaCl diet significantly reduced renal blood flow to 6.0 ml/min/g compared to 7.9 ml/min/g in sham rats on a normal diet (P<0.05).
High sodium intake impairs dynamic autoregulation of renal blood flow in angiotensin II-infused rats, an effect that is attenuated by the superoxide scavenger tempol.
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High sodium may impair renal autoregulation in angiotensin II states; leaves open human translation and clinical relevance.
The aim of this study was to investigate dynamic autoregulation of renal blood flow (RBF) in ANG II-infused rats and the influence of high-NaCl intake. Sprague-Dawley rats received ANG II (250 ng·kg(-1)·min(-1) sc) or saline vehicle (sham) for 14 days after which acute renal clearance experiments were performed during thiobutabarbital anesthesia. Rats (n = 8-10 per group) were either on a normal (NNa; 0.4% NaCl)- or high (HNa; 8% NaCl)-NaCl diet. Separate groups were treated with 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (tempol; 1 M in drinking water). Transfer function analysis from arterial pressure to RBF in the frequency domain was used to examine the myogenic response (MR; 0.06-0.09 Hz) and the tubuloglomerular feedback mechanism (TGF; 0.03-0.06 Hz). MAP was elevated in ANG II-infused rats compared with sham groups (P < 0.05). RBF in ANG II HNa was reduced vs. sham NNa and sham HNa (6.0 ± 0.3 vs. 7.9 ± 0.3 and 9.1 ± 0.3 ml·min(-1)·g kidney wt(-1), P < 0.05). transfer function gain in ANG II HNa was significantly elevated in the frequency range of the MR (1.26 ± 0.50 dB, P < 0.05 vs. all other groups) and in the frequency range of the TGF (-0.02 ± 0.50 dB, P < 0.05 vs. sham NNa and sham HNa). Gain values in the frequency range of the MR and TGF were significantly reduced by tempol in ANG II-infused rats on HNa diet. In summary, the MR and TGF components of RBF autoregulation were impaired in ANG II HNa, and these abnormalities were attenuated by tempol, suggesting a pathogenetic role for superoxide in the impaired RBF autoregulatory response.
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Saeed et al. (2010) studied ANG II-induced hypertension. High-NaCl diet and ANG II infusion vs. Normal NaCl diet (0.4% NaCl) and saline vehicle (sham) was evaluated on Renal blood flow (ml·min(-1)·g kidney wt(-1)) (p=<0.05). In ANG II-infused rats, a high-NaCl diet significantly reduced renal blood flow to 6.0 ml/min/g compared to 7.9 ml/min/g in sham rats on a normal diet (P<0.05).
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