Why the study?
Do endothelin receptor antagonists improve renal hemodynamics and dynamic renal blood flow autoregulation in Angiotensin II-infused rats on high NaCl intake?
Do endothelin receptor antagonists improve renal hemodynamics and dynamic renal blood flow autoregulation in Angiotensin II-infused rats on high NaCl intake?
Selective ETA antagonism reduces arterial pressure and increases outer medullary perfusion in Ang II-infused rats on high salt intake, but these benefits depend on intact ETB receptor stimulation and do not correct abnormal renal blood flow autoregulation.
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Supports ETA antagonism for medullary perfusion in Ang II-salt rat models; leaves open ETB dependence and human translation.
Saeed et al. (2012) studied this question.
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