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August 19, 2003HypertensionOpen Access

Endothelin-A Receptors Mediate Renal Hemodynamic Effects of Exogenous Angiotensin II in Humans

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Why the study?

Does endothelin-A blockade with BQ123 reduce Angiotensin II-induced renal and systemic vasoconstriction in healthy volunteers?

Population

7 healthy volunteers on a 250-mmol sodium diet

Comparison

Angiotensin II infusion combined with… vs Angiotensin II infusion alone

Design

Other

Authors

AMAlberto MontanariUniversidad IberoamericanaABA BiggiFederico II University HospitalNCNicoletta CarraUniversity of Parma

Discussion

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Implication

Endothelin-A blockade attenuates Ang II vasoconstriction in healthy volunteers; leaves open therapeutic relevance in hypertension.

Structured PICO

Does endothelin-A blockade with BQ123 reduce Angiotensin II-induced renal and systemic vasoconstriction in healthy volunteers?

P
Population
7 healthy volunteers on a 250-mmol sodium diet
I
Intervention
Angiotensin II infusion (increasing rates of 0.625, 1.25, and 2.5 ng/kg per minute, each for 30 minutes) combined with endothelin-A blocker BQ123 (0.4 nmol/kg per minute)
C
Comparator
Angiotensin II infusion alone (and a third study of BQ123 infusion alone)
O
Outcome
Renal hemodynamic changes including renal blood flow, glomerular filtration rate, filtration fraction, mean arterial pressure, and renal vascular resistancesurrogate

Endothelin-A receptors contribute substantially to the systemic and renal vasoconstriction induced by low-dose exogenous Angiotensin II in healthy humans.

Cite This Study

Montanari et al. (2003) studied this question.

synapsesocial.com/papers/6a815e8cadfa6baaaee1cf4fhttps://doi.org/10.1161/01.hyp.0000088361.26773.08
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of endothelin receptor subtypes in the systemic and renal responses to endothelin-1 in humans.1997 · 54 citations
  2. 2Endothelin-1 augments pressor response to angiotensin II infusion in rats.1992 · 59 citations
  3. 3ETA receptors mediate vasoconstriction, whereas ETB receptors clear endothelin-1 in the splanchnic and renal circulation of healthy men2003 · 53 citations
  4. 4Reciprocal Influence of Salt Intake on Adrenal Glomerulosa and Renal Vascular Responses to Angiotensin II in Normal Man1974 · 333 citations
  5. 5Endothelin Mediates Some of the Renal Actions of Acutely Administered Angiotensin II2001 · 43 citations