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July 1, 2001HypertensionOpen Access

Endothelin Mediates Some of the Renal Actions of Acutely Administered Angiotensin II

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Population

Conscious, chronically catheterized rats

Comparison

Bosentan or BQ-123 administered during acute… vs Acute intravenous infusion of angiotensin II…

Design

Preclinical

Follow-up

acute

Authors

ARAmy RigglemanWake County Human ServicesJHJeff HarveyWest Virginia UniversityCBChris BaylisMondelēz International (United Kingdom)

Discussion

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Implication

Endothelin-angiotensin interactions in rats warrant further study; leaves open any role in human hypertension management.

Structured PICO

P
Population
Conscious, chronically catheterized rats
I
Intervention
Bosentan (mixed endothelin-A and endothelin-B receptor antagonist) or BQ-123 (endothelin-A-selective blocker) administered during acute intravenous infusion of angiotensin II (low dose: 0.48 pmol/0.5 ng/100 g body weight per min; high dose: 1.91 pmol/2.0 ng/100 g body weight per min)
C
Comparator
Acute intravenous infusion of angiotensin II without endothelin antagonists
O
Outcome
Mean arterial blood pressure and renal vascular resistancesurrogate

Endothelin, primarily via the endothelin A receptor, mediates the pressor, renal vasoconstrictor, natriuretic, and diuretic actions of acutely administered angiotensin II in a rat model.

Cite This Study

Riggleman et al. (2001) studied this question.

synapsesocial.com/papers/6a815e8cadfa6baaaee1cf54https://doi.org/10.1161/01.hyp.38.1.105
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries.1992 · 269 citations
  2. 2Actions of endogenous endothelin on glomerular hemodynamics in the rat1995 · 44 citations
  3. 3Renal effects of acute endothelial-derived relaxing factor blockade are not mediated by angiotensin II1993 · 70 citations
  4. 4Effect of Endothelin on Regional Hemodynamics and Renal Function in Awake Normotensive Rats1989 · 44 citations
  5. 5Vascular and cardiac overexpression of endothelin-1 gene in one-kidney, one clip Goldblatt hypertensive rats but only in the late phase of two-kidney one clip Goldblatt hypertension1996 · 60 citations