Why the study?
Does endothelin-A blockade alter renal hemodynamics under angiotensin II blockade in healthy volunteers?
Population
6 healthy volunteers on a 240 mmol Na diet
Comparison
Endothelin-A blocker BQ-123 after pretreatment… vs BQ-123 after placebo, BQ-123 + telmisartan +…
Design
Other
Follow-up
90 minutes per infusion
Authors
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Supports NO-dependent renal vasodilation by ET-A blockade during ARB in healthy volunteers; leaves open therapeutic implications for patients with hypertension or CKD.
Does endothelin-A blockade alter renal hemodynamics under angiotensin II blockade in healthy volunteers?
Endothelin-A blockade produces significant renal vasodilation when angiotensin II receptors are blocked, a process that is dependent on nitric oxide.
Montanari et al. (2002) studied this question.
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