Why the study?
Do higher blood cyclosporine concentrations reduce the risk of histologically confirmed acute rejection in heart transplant recipients?
Do higher blood cyclosporine concentrations reduce the risk of histologically confirmed acute rejection in heart transplant recipients?
Maintaining blood cyclosporine concentrations above 375 microgram L(-1) during the first 3 months post-heart transplantation optimally protects against acute allograft rejection.
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May support targeting cyclosporine >375 μg/L to lower early rejection risk; hypothesis-generating and requires randomized confirmation.
Best et al. (1996) studied this question.
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