March 1, 2003Canadian Journal of Physiology and Pharmacology

Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells

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Population

Primary culture of human aortic vascular smooth muscle cells (hVSMCs)

Comparison

Angiotensin II (10 to 10 M) exposure and… vs Native/normal hVSMCs without Angiotensin II or…

Design

Preclinical

Authors

GBGhassan BkailyUniversité de Sherbrooke SSSama F. SleimanLebanese American University JSJoseph S. StephanLebanese American University

Discussion

Member takes

Implication

May alter vascular calcium via nuclear AT1R; hypothesis-generating for human hypertension therapies.

Structured PICO

Population

Primary culture of human aortic vascular smooth muscle cells (hVSMCs)

Intervention

Angiotensin II (10(-15) to 10(-4) M) exposure and hAT1R/hAT1R-GFP overexpression

Comparator

Native/normal hVSMCs without Angiotensin II or overexpression

Outcome

hAT1R internalization, nuclear translocation, de novo synthesis, and modulation of free cytosolic ([Ca]c) and nuclear ([Ca]n) calciumsurrogate

Angiotensin II induces rapid internalization, nuclear translocation, and de novo synthesis of AT1 receptors in human aortic smooth muscle cells, which modulates intracellular calcium dynamics.

Cite This Study

Bkaily et al. (2003) studied this question.

synapsesocial.com/papers/6a8fda68576e8630a94fd4e7 https://doi.org/10.1139/y03-007

View Full Paper

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Bookmark

Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider