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August 27, 2026International Journal of Transgender Health

Phenotypic shift to hidradenitis suppurativa conglobata following testosterone therapy in a transgender man

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Authors

SAS. AbboudMDM. DaoudVMV. Del Marmol

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Overview

Case report demonstrates a severe hidradenitis suppurativa conglobata shift following testosterone therapy in a transgender man, highlighting cutaneous side effects of masculinizing hormone therapy.

Key Points

  • To document a case of phenotypic evolution to severe hidradenitis suppurativa conglobata in a transgender man undergoing masculinizing hormone therapy.
  • Clinical and dermatological evaluation of a transgender male patient receiving testosterone therapy for gender affirmation.
  • Testosterone therapy was linked to the exacerbation and phenotypic progression of follicular occlusion to severe hidradenitis suppurativa conglobata.
  • The findings underscore androgen-driven pathways in follicular inflammation and the need for proactive dermatologic management in gender-affirming care.

Cite This Study

Abboud et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe99110c91c1e9262145fhttps://doi.org/10.1080/26895269.2026.2721580
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gynecologic function and dysfunction in transmasculine and gender diverse individuals using testosterone therapy: a systematic review2026
  2. 2The Effects of Testosterone Gender-Affirming Hormonal Therapy on Body Composition and Psychosocial Well-being in Transmen2026
  3. 3Systemic testosterone induces structural, immunological, and sex steroid receptor changes in human XX skin2026
  4. 4Spectrum of Histopathologic Findings in Transgender Men Undergoing Gender-Affirming Gynecologic Surgery Following Preoperative Androgen Therapy: A Tertiary Care Center Study2025
  5. 5Gender Affirming Hormonal Therapy Induces a Gender-Concordant Gut Metagenome Transition in Transgender Individuals2024