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August 27, 2026European Heart Journal OpenOpen Access

Effect of low-flow oxygen therapy on 6MWD in PAH and CTEPH: a randomized non-inferiority crossover trial

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Authors

CWCarmen WickMLMona LichtblauATAnna Titz

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Overview

Randomized noninferiority trial demonstrates non-inferior walk distance with ambient air versus oxygen in pulmonary hypertension, suggesting routine portable oxygen provides selective benefits.

Key Points

  • To determine whether ambient air is non-inferior to pulsed low-flow supplemental oxygen therapy delivered by a portable concentrator regarding six-minute walk distance in patients with PAH or CTEPH.
  • Randomized non-inferiority crossover trial (NCT06384534) in 40 patients (mean age 62±15 years; 21 female; 20 PAH, 20 CTEPH) with exercise-induced desaturation >3%.
  • Participants performed two six-minute walk distance (6MWD) tests in randomized order: breathing ambient air versus pulsed low-flow (1–2 L/min) nasal oxygen via a backpack portable concentrator, using a predefined non-inferiority margin of –35 m.
  • Ambient air was non-inferior to supplemental oxygen for 6MWD with a mean difference of 0 m (95% CI: –15 to 14 m, p < 0.001 for non-inferiority), though 5 patients exceeded the minimal clinically important difference of 35 m on oxygen.
  • At end-exercise, supplemental oxygen reduced desaturation by 2% (95% CI: –3 to –0.2%, p = 0.025) and reduced dyspnea by 1 point (95% CI: 0.3 to 1, p < 0.002), with symptom improvements present in PAH but not in CTEPH.

Cite This Study

Wick et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe99e10c91c1e926214f7https://doi.org/10.1093/ehjopen/oeag125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of supplemental oxygen therapy on six-minute walk distance in patients with pulmonary arterial hypertension living at 2850m: a randomized, crossover trial2026
  2. 2Effect of short-term supplemental oxygen therapy on six-minute walk distance in highlanders at risk for pulmonary hypertension: a randomized, crossover trial2025
  3. 3A65-12 Supplemental Oxygen Decreases Cardiac Effort in Pulmonary Arterial Hypertension2026
  4. 4Oxygen supplementation in ambulatory patients with heart failure: a randomized proof-of-concept study2025 · 2 citations
  5. 5Long-term oxygen therapy in precapillary pulmonary hypertension – SOPHA study2024