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April 30, 2025European Heart Journal OpenOpen Access

Oxygen saturation during 6MWT was higher with POC ON (at 6 min, +2.8%, 95% CI 2.2-3.3%) and perceived exertion was significantly lower (at 6 min, -0.75, 95% CI -1.1 to -0.4).

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Why the study?

The short-term physiological and symptom responses to oxygen therapy during ambulation in patients with chronic heart failure were not well characterized.

Does oxygen supplementation improve peripheral oxygen saturation and symptoms during ambulation in patients with chronic heart failure?

Population

20 participants with chronic HF

Comparison

Oxygen via portable concentrator (POC ON) vs no oxygen (POC OFF) during 6MWTs

Design

Pilot randomized cross-over study

Follow-up

Same day

Authors

MTMaxime Tremblay‐GravelANAnna NozzaSGStanislav Glezer

Discussion

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Member takes

Overview

Supports symptomatic relief with supplemental oxygen during activity in chronic HF; pilot data leaves larger outcome trials needed before practice change.

Structured PICO

Does oxygen supplementation improve peripheral oxygen saturation and symptoms during ambulation in patients with chronic heart failure?

P
Population
n=20 adults with chronic heart failure, mean age 70 ± 10 years, mean LVEF 33% ± 10%
I
Intervention
Oxygen supplementation via portable oxygen concentrator (POC ON) during a 6-minute walk test
C
Comparator
No oxygen supplementation (POC OFF) during a 6-minute walk test (cross-over design)
O
Outcome
Peripheral oxygen saturation, heart rate, and modified BORG scale during 6-minute walk testsurrogate

Supplemental oxygen during physical activity improves peripheral oxygen saturation and reduces perceived exertion in symptomatic patients with chronic heart failure.

Cite This Study

Tremblay‐Gravel et al. (2025) studied this question.

synapsesocial.com/papers/6a83fe2a4d653d38678deedfhttps://doi.org/10.1093/ehjopen/oeaf074
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