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June 6, 2026ERJ Open ResearchOpen Access

Effect of supplemental oxygen therapy on six-minute walk distance in patients with pulmonary arterial hypertension living at 2850m: a randomized, crossover trial

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Authors

DHDinah HertigMFMichael FurianMLMona Lichtblau

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Overview

Randomized trial investigates supplemental oxygen therapy's effect on exercise capacity in high-altitude PAH patients, suggesting inadequate benefits.

Key Points

  • This study examines the impact of low-dose supplemental oxygen therapy on exercise capacity in patients with pulmonary arterial hypertension living at high altitude.
  • Randomized crossover trial design, comparing 6-minute walk distance with and without supplemental oxygen therapy.
  • Testing conducted at 2850 m altitude, involving 28 adults diagnosed with pulmonary arterial hypertension.
  • Measurements included 6MWD, heart rate, blood pressure, and peripheral oxygen saturation.
  • Supplemental oxygen therapy did not significantly improve 6MWD (mean difference −5 m, 95% CI: −24 to 14 m, p=0.576).
  • No improvement in dyspnea or leg discomfort was observed with SOT compared to hypoxic air.
  • Resting peripheral oxygen saturation increased, but not during exertion.

Cite This Study

Hertig et al. (2026) studied this question.

synapsesocial.com/papers/6a23ba8771a5da9775e76403https://doi.org/10.1183/23120541.01671-2025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of short-term supplemental oxygen therapy on six-minute walk distance in highlanders at risk for pulmonary hypertension: a randomized, crossover trial2025
  2. 2Effect of low-flow oxygen therapy on 6MWD in PAH and CTEPH: a randomized non-inferiority crossover trial2026
  3. 3A65-12 Supplemental Oxygen Decreases Cardiac Effort in Pulmonary Arterial Hypertension2026
  4. 4The effect of high altitude on exercise capacity and cardiorespiratory function in patients with pulmonary vascular disease after an overnight stay at 2500 m – a randomized cross-over study2026
  5. 5The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled cross-over trial2024 · 11 citations