What does this research mean for the field?

Cardioplegic total cardiopulmonary bypass is associated with an early increase in circulating VCAM-1 compared to beating-heart partial bypass, suggesting a configuration-associated endothelial response. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare circulating endothelial-associated biomarkers and tissue expression between beating-heart partial cardiopulmonary bypass and cardioplegic total cardiopulmonary bypass in a juvenile swine model.

August 27, 2026Veterinary SciencesOpen Access

Circulating Endothelial-Associated Biomarker Responses During Beating-Heart Partial Versus Cardioplegic Total Cardiopulmonary Bypass in Juvenile Pigs: An Exploratory Comparative Study

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Authors

HUHiromu UdagawaRakuno Gakuen University YHYuji HamamotoOsaka University of Economics ENEunryel NamRakuno Gakuen University

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Implication

Experimental study reveals increased serum VCAM-1 levels during cardioplegic total versus partial cardiopulmonary bypass in juvenile pigs, indicating configuration-dependent endothelial activation.

Key Points

To compare circulating endothelial-associated biomarkers and tissue expression between beating-heart partial cardiopulmonary bypass and cardioplegic total cardiopulmonary bypass in a juvenile swine model.
Ten 8-week-old female crossbred piglets were assigned to undergo either 60 minutes of partial CPB with a beating heart (n = 5) or total CPB with aortic cross-clamping and cardioplegic arrest (n = 5).
Circulating serum concentrations of VCAM-1, ADAM-17, and TSP-1 were measured using ELISA, and tissue expressions of VCAM-1 and PECAM-1 were evaluated via immunohistochemistry.
At the end of CPB, serum VCAM-1 was significantly higher in the total CPB group compared to the partial CPB group (Hodges–Lehmann location shift = 341.7 ng/mL, 95% CI, 5.1–607.0 ng/mL; |rank-biserial r| = 0.84, 95% CI, 0.36–1.00; p = 0.03).
Circulating ADAM-17 and TSP-1 concentrations, as well as tissue VCAM-1 and PECAM-1 findings, showed no consistent differences between the two CPB groups.

Cite This Study

Udagawa et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9da10c91c1e92621dac https://doi.org/10.3390/vetsci13090861

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Implication

Experimental study reveals increased serum VCAM-1 levels during cardioplegic total versus partial cardiopulmonary bypass in juvenile pigs, indicating configuration-dependent endothelial activation.

Circulating Endothelial-Associated Biomarker Responses During Beating-Heart Partial Versus Cardioplegic Total Cardiopulmonary Bypass in Juvenile Pigs: An Exploratory Comparative Study

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Implication

Key Points

Cite This Study

Circulating Endothelial-Associated Biomarker Responses During Beating-Heart Partial Versus Cardioplegic Total Cardiopulmonary Bypass in Juvenile Pigs: An Exploratory Comparative Study

Discussion

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Implication

Key Points

Cite This Study

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