Population
Cultured human umbilical-vein endothelial cells prelabeled with [14C]-arachidonic acid
Comparison
Laminar shear stresses of 0.4, 1.4 and 22… vs Baseline/initial values and agonist-stimulated…
Design
Preclinical
Follow-up
up to 30 min
Authors
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No immediate clinical implications; leaves open whether shear-induced phospholipid turnover drives chronic endothelial adaptation in vivo.
Fluid shear stress stimulates membrane phospholipid metabolism in human endothelial cells, suggesting chronic stimulation of endothelial-cell metabolism by flow.
Bhagyalakshmi et al. (2008) studied this question.
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