Why the study?
Does systemic infusion of endothelin-1 alter whole body and renal noradrenaline release in conscious sheep?
Does systemic infusion of endothelin-1 alter whole body and renal noradrenaline release in conscious sheep?
Acute systemic infusion of endothelin-1 in conscious sheep increases mean arterial pressure and decreases renal noradrenaline spillover, suggesting a baroreflex-mediated reduction in renal sympathetic vasoconstrictor activity.
ET-1 selectively lowers renal NA spillover in sheep; leaves open translation to human sympathetic regulation in hypertension.
The present study investigated in conscious sheep the response of the sympathetic nervous system to a systemic infusion of 20 nmol/h endothelin-1 (ET-1), using a tritiated-noradrenaline (NA) tracer dilution technique. 2. Mean arterial pressure increased from 79 +/- 3 mmHg to a maximal level of 102 +/- 12 mmHg by 30 min of ET-1 infusion. 3. Total and renal NA kinetics were measured during this time. Total NA spillover was not affected by infusion of ET-1. In contrast, renal NA spillover decreased from a control level of 81 +/- 5 to 30 +/- 14 ng/min (P < 0.01) after 20 min and to 27 +/- 7 ng/min (P < 0.01) after 30 min of ET-1 infusion. 4. The present findings are consistent with the proposal that a direct vasoconstrictor action of ET-1 results in a paroreflex mediated reduction in renal sympathetic vasoconstrictor activity.
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Mathai et al. (1995) studied this question.
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