Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Pericardial effusion (n=54). Intervention: CRP/albumin ratio vs. Lower CRP/albumin ratio. Primary outcome: In-hospital mortality (OR 0.600, 95% CI 0.406-0.888, p=0.011).

Uğur Küçük; Emıne Gazı; Bahadır Kırılmaz

doi:10.47482/acmr.2021.29

September 27, 2021Archives of Current Medical ResearchOpen Access

Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis

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Key result

Elevated CRP/albumin ratios were associated with in-hospital mortality in patients undergoing pericardiocentesis.

Why the study?

Routinely available parameters to predict prognosis in patients undergoing pericardiocentesis are limited, though CRP/albumin ratios associate with prognosis in other conditions.

Do CRP/albumin and CRP/pericardial fluid albumin ratios predict in-hospital mortality in patients undergoing pericardiocentesis?

Study Design

Type

Observational (n=54)

Multicenter

No

Structured PICO

Do CRP/albumin and CRP/pericardial fluid albumin ratios predict in-hospital mortality in patients undergoing pericardiocentesis?

P

Population

54 patients (mean age 68 years, 46% female) with moderate-to-large pericardial effusions undergoing first-time pericardiocentesis, evaluated for in-hospital mortality.

E

Exposure

Measurement of C-reactive protein (CRP) to serum albumin ratio and CRP to pericardial fluid albumin (CRP/pf-albumin) ratio

O

Outcome

In-hospital mortalityhard clinical

Main Result

Odds Ratio: 0.6 (95% CI 0.406–0.888)

p-value: p=0.011

Elevated CRP/albumin and CRP/pericardial fluid albumin ratios are strong, easily calculated predictors of in-hospital mortality in patients undergoing pericardiocentesis.

Limitations

Single-center study with a small number of patients
Retrospective design
No information on long-term outcomes for patients discharged with recovery
single-center study
small number of patients
retrospective study without long-term follow-up data

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Implication

Should not yet guide pericardiocentesis risk assessment; leaves open the prognostic value of CRP/albumin ratio.

Abstract

Background: Pericardial effusions occur due to excessive fluid accumulation in the pericardial space. In effusions not responding to medical treatment, pericardiocentesis is an important method of treatment affecting prognosis. CRP/albumin ratios have been found to be associated with prognosis in conditions such as cardiac failure, sepsis, malignancy, and the routinely available parameters used for the prognosis prediction of the patients who underwent pericardiocentesis are limited. This study aimed to examine the usability of CRP/albumin and CRP/pericardial fluid albumin (CRP/pf-albumin) ratios as predictors for in-hospital mortality of patients who underwent surgery pericardiocentesis.

Discussion

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Cite This Study

Küçük et al. (2021) conducted an observational in Pericardial effusion (n=54). CRP/albumin ratio vs. Lower CRP/albumin ratio was evaluated on In-hospital mortality (OR 0.600, 95% CI 0.406-0.888, p=0.011). Elevated CRP/albumin ratios were associated with in-hospital mortality in patients undergoing pericardiocentesis.

synapsesocial.com/papers/6a900f4415c14a52f9041512 https://doi.org/10.47482/acmr.2021.29

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Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis

Study Design

Structured PICO

Main Result

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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