Why the study?
Does dichloroacetate improve contractility and restore triacylglyceride content in hypertrophied rat hearts?
Population
Sham-operated (SHAM) and aortic banded rat hearts (HYP)
Comparison
Dichloroacetate to activate pyruvate dehydrogenase vs Untreated hearts
Design
Preclinical
Follow-up
30 minutes
Authors
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Supports metabolic targets in experimental hypertrophy; leaves open translation to human heart failure therapies.
Does dichloroacetate improve contractility and restore triacylglyceride content in hypertrophied rat hearts?
Activating pyruvate dehydrogenase with dichloroacetate partially reverses increased anaplerosis, restores triacylglyceride content, and improves contractility in hypertrophied rat hearts.
Pound et al. (2009) studied this question.
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