August 4, 2009Cardiovascular Therapeutics

Neuroendocrine Effects on the Heart and Targets for Therapeutic Manipulation in Heart Failure

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Population

Patients with chronic heart failure (CHF)

Design

Review

Authors

PCParminder S ChaggarRoyal Cornwall Hospital Trust CMChris J. MalkinLeeds General Infirmary SSSteven M. ShawManchester University NHS Foundation Trust

Discussion

Member takes

Implication

Anabolic axis pilots yield inconsistent surrogate signals in HF; hypothesis-generating only, with no support for clinical adoption pending RCTs.

Structured PICO

Population

Patients with chronic heart failure (CHF)

Intervention

Neuroendocrine treatment strategies including testosterone, growth hormone, insulin-like growth factor-1, and growth hormone secretagogues

This review highlights the role of neurohormonal derangements in chronic heart failure and explores potential therapeutic strategies targeting anabolic axes.

Cite This Study

Chaggar et al. (2009) studied this question.

synapsesocial.com/papers/6a9012b4b9c81af07e3404e2 https://doi.org/10.1111/j.1755-5922.2009.00094.x

Topics

Heart failure HFrEF treatment

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Ask AI

Bookmark

Implication

Anabolic axis pilots yield inconsistent surrogate signals in HF; hypothesis-generating only, with no support for clinical adoption pending RCTs.

Neuroendocrine Effects on the Heart and Targets for Therapeutic Manipulation in Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Neuroendocrine Effects on the Heart and Targets for Therapeutic Manipulation in Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider